ILC Dover Shares Testing Results for EZJetFlo for Powder Dissolution and Mixing 

ILC Dover, an Ingersoll Rand business, has shared results from recent testing of its EZJetFlo technology, an in-line powder induction and mixing system designed to support biopharmaceutical manufacturing with simplified operations, improved consistency, and accelerated production.

EZJetFlo is designed to help address powder dissolution challenges in bioprocessing, such as incomplete wetting, powder agglomeration, and long mixing times that can impact batch quality, process efficiency, and scalability. Through a Venturi-based design that rapidly entrains powders into a high-velocity liquid stream, EZJetFlo enables immediate wetting, dispersion, and dissolution in a fully closed, single-use process.

Recent testing has shown that EZJetFlo Technology demonstrated significant improvements in powder induction and mixing performance at a 900-liter scale.

The system operates in closed-loop recirculation mode, where accelerated liquid flow creates a vacuum of approximately –900 mbar, drawing powders directly into the process stream. This approach eliminates many of the limitations associated with traditional vessel-based mixing methods while providing consistent flow dynamics and streamlined operation.

“Biopharmaceutical manufacturers are under constant pressure to improve productivity while maintaining product quality and process control,” said Paulo Bento, Director, Process Equipment & Field Applications. “EZJetFlo Technology delivers a scalable, efficient solution that helps customers reduce processing times, improve mixing consistency, and simplify operations in media and buffer preparation applications.”

Key performance findings include:

                  •               Faster powder induction: Powder feed rates increased by approximately 25% when pump speed increased from 61% to 71%, demonstrating the direct relationship between process flow and Venturi-driven suction performance.


                  •               Broad material compatibility: Stable, uninterrupted powder feeding was achieved across multiple materials, including sodium hydroxide (NaOH), glucose, and starch, without clogging or operational disruption.


                  •               Rapid dissolution: For highly soluble materials such as NaOH, pH measurements shifted almost instantaneously from approximately pH 6 to pH 12, indicating fast dissolution and homogeneous distribution throughout the system.


                  •               Mixing efficiency: More than 99.5% of solids dissolved within 2–3 minutes, with less than 0.5% retained particles observed on a 60-mesh screen, even when processing more challenging formulations.